FIZIOTENZ table. 0.4 mg. 28 tablets
Fiziotens is a selective imidazoline receptor agonist (Syrah). In various animal models Fiziotens has shown that a strong antihypertensive action. Available experimental data indicate that the site of antihypertensive action is Fiziotens CNS (central nervous system). Has been shown to selectively activate Fiziotens called. imidazoline receptors in the brainstem.
FIZIOTENZ table. 0.4 mg. 28 tablets
How does Fiziotens?
Fiziotens is a selective imidazoline receptor agonist (Syrah). In various animal models Fiziotens has shown that a strong antihypertensive action. Available experimental data indicate that the site of antihypertensive action is Fiziotens CNS (central nervous system). Has been shown to selectively activate Fiziotens called. imidazoline receptors in the brainstem. These receptors are crucial for the central control of peripheral sympathetic nervous system activation Their reduces sympathetic activity and lower blood pressure.
Fiziotens differs in that it exhibits only a weak affinity for the known alpha-2-adrenoreceptors in relation to its effects on imidazoline receptors. This affinity explains the low incidence of depression of the nervous system (calming) or dry mouth when administering Fiziotens.
In humans Fiziotens reduces systemic resistance vessels and thus reduce blood pressure. Fiziotens antihypertensive effect has been proven in double-blind, placebo-controlled, randomized clinical trials. . Within two therapeutic study has found Mr. improve insulin sensitivity by 21% with the use of Fiziotens compared to placebo in obese and insulin resistant substation with an average speed hypertension.
Before taking Fiziotens
Fizpoteps not take if:
You are allergic to any ingredient of the product
Suffer from the syndrome or sick sinus bradycardia (heart rate in a state of rest is below 50 beats per minute).
Take special care when taking Fiziotens:
If Fiziotens is used concomitantly with beta-blocker and if both drugs should be discontinued, the beta-blocker should be stopped first and only then to stop Fiziotens.
When taken with other medicines:
Please tell your doctor or pharmacist if you are taking or have recently used any other medicines, even those not prescribed.
Concomitantly with other drugs for high blood pressure:
Fiziotens used safely with diuretics and calcium channel blockers. Concomitant administration of these and other antihypertensive drugs resulted in additive (pooled effect overlaying effects) efekt.Pri healthy volunteers, there were no pharmacokinetic interactions when administering Fiziotens with hydraulic ohlortiazid, glibenclamide (glyburide) or digoksin.Tay as tricyclic antidepressants may reduce the effects of centrally acting antihypertensive drugs is not recommended tritsiklinichni antidepressants are administered concomitantly with Fiziotens. There were no interactions with any farmokodinamichni moklobemid.Fiziotens leads to an improvement of impaired kongnitivna (cognitive) function in patients receiving lorazepam. Fiziotens may potentiate the sedative (tranquilizing) effects of benzodiazepines when administered concomitantly.
No clinical studies Fiziotens child. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal / fetal development, parturition or postnatal period. Caution when prescribing to pregnant women.
Fiziotens is excreted in breast milk. Women in lactation period should be advised not to breastfeed when Fiziotens treatment or stop taking the drug.
Driving and operating machinery
There is no evidence to suggest that Fiziotens adversely affects driving or operating machinery. Drowsiness and dizziness. This should be considered in the implementation of these activities.
Important information about some of the ingredients of Fiziotens
Lactose monohydrate: If your doctor has told you have an intolerance to some sugars, contact your doctor before taking this medicine.
How to take Fiziotens?
The usual starting dose is 0.2 mg Fiziotens day with a maximum daily dose of 0.6 mg given as two divided doses. The maximum single dose that can be given is 0.4 mg. The daily dose is determined according to the individual response to patsienta.Fiziotens can be taken with or without hrana.Pri patients with moderate to severe renal impairment, the starting dose is 0.2 mg daily. If necessary and well tolerated, the dose may be increased to 0.4 mg dnevno.Pri hemodialysis patients starting dose is 0.2 mg daily. If necessary and well tolerated, the dose may be increased to 0.4 mg dnevno.Ne defined safety and effectiveness of Fiziotens in patients under 18 years.
If you take too much Fiziotens than you should:
Symptoms of overdose
There have been some cases of overdose in absorbed dose to 16 mg with no fatalities. Reported signs and symptoms include headache, sedapiya, drowsiness, low blood pressure, dizziness, weakness, bradycardia (slow heart rate), dry mouth, vomiting, fatigue and abdominal pain.
In cases of overdose, according to data from several toxicological studies on animals can get hypertension (high blood pressure), tachycardia (rapid heartbeat) and hyperglycemia (high blood sugar).
Management of overdose
There is no specific antidote. In cases of hypotension (low blood pressure) is recommended circulation maintenance such as fluid intake and administration of dopamine. Bradycardia can be treated with atropine, alpha-receptor antagonist could reduce or eliminate paradoxical hypertensive effect of over dosage Fiziotens.
If you forgot to take your dose Fiziotens
Do not take a double dose to make up for a missed dose.
Effects of discontinuation of Fiziotens
Fiziotens therapy should not be discontinued abruptly.
Possible side effects of Fizioten
Like all medicines, Fiziotens can have side effects. If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Common (incidence of 1 -10%), headache, dizziness, drowsiness, dry mouth, weakness. Uncommon (<1%), sleep disturbances, nausea, skin rashes, itching rare (incidence <0.1%), hypotension, orthostatic hypotension (drop in blood pressure when getting up suddenly)
Very rare (incidence <0.01%) angioedema
Fiziotens 0.4 mg: do not store above 30 ° C.
Keep the medicine in the original container.
Do not use after the expiry date stated on the packaging. Keep this medicine out of the reach of children.
Fiziotens 0.4 mg: 3 years
The active substance is 0.4 mg moxonidine. The ingredients are: lactose, povidone, crospovidone, magnesium stearate, хидорксипорпилметилцелулоза, ethyl cellulose, polyethylene glycol 600, talc, red iron oxide (E172), titanium dioxide (E 171).