Metostad CR 100 mg. 30 tablets

€15

Metoprolol succinate, the active substance in Method CR, belongs to a group of medicines called selective beta-receptor blockers that act in particular on the heart.

Quantity

Metostad CR 100 mg. 30 tablets

What is Metostad CR and what it is used for
Metoprolol succinate, the active substance in Method CR, belongs to a group of medicines called selective beta-receptor blockers that act in particular on the heart. This drug affects the body's response to some nervous signals, especially in the heart. As a result, it lowers blood pressure and increases the pumping power of the heart.

[Metostad CR 23.75 mg]
Metostad CR is used in adults for:

treatment of mild to moderate stable chronic heart failure (heart failure) (with left ventricular lesion function) in addition to standard therapy.
[Metostad CR 47.5 mg / 95 mg / 190 mg
Metostad CR is used in adults for:

treatment of mild to moderate stable chronic heart muscle weakness (with left ventricular function) in addition to standard therapy;
treatment of high blood pressure (hypertension);
treatment of poor blood supply to the coronary arteries (ischemic heart disease, angina);
treatment of heart rhythm disorders (tachycardic arrhythmias), especially if they occur in the aorta (supraventricular tachycardia);
to prevent a recurrent heart attack after a sustained heart attack (maintenance therapy);
treatment of functional cardiovascular disorders;
prevention of migraine.
Metostad CR is used in children and adolescents aged 6-18 years for:

treatment of high blood pressure (hypertension).
2. What you need to know before you accept Method CR
Do not accept Metostad CR

if you are allergic to metoprolol, other beta-receptor blockers or any of the other ingredients of this medicine (listed in section 6);
if you have certain types of heart rhythm abnormality (second or third degree AV block, high grade sinatrix block);
if you have a slow heart rate (pulse <50 beats / minute);
if you suffer from dysfunction of the sinus node in the heart (sick sinus syndrome);
if you have experienced a circulatory collapse, mainly due to heart failure;
if you suffer from severe blood circulation disorders in your hands and / or feet;
if you suffer from pathologically low blood pressure, that is, when the systolic value (upper blood pressure) is less than 90 mmHg;
if you suffer from an untreated hormone-producing adrenal medulla (pheochromocytoma);
if you have high levels of acidity in your blood caused by a metabolic disorder;
if you suffer from a severe form of bronchial asthma or chronic pulmonary disease that clogs the bronchi;
if you are also being treated with MAOI (medicines used to treat depression with the exception of MAO-B inhibitors);
if a heart attack is suspected and the pulse is below 45 beats / minute, the upper blood pressure is <100 mmHg and some types of heart rhythm are present;
if you use other medicines to lower your blood pressure such as verapamil and diltiazem;
if you are using antiarrhythmic drugs such as disopyramide.
Patients with chronic heart failure should not take metoprolol:

if they suffer from unstable, decompensated heart failure (which may occur as fluid accumulation in the lungs, poor blood circulation or low blood pressure), unless this condition is stabilized by medication treatment;
if you receive permanent or temporary treatment with medicines that increase the heart's pumping power (for example, dobutamine);
if their systolic (upper) blood pressure is consistently below 100 mmHg.
Warnings and precautions
Talk to your doctor or pharmacist before taking Metoda CR if you have one or more of the following symptoms or if you get any of these signs during treatment:

if you suffer from bronchial asthma: Metoprolol may worsen the symptoms of bronchial asthma. The effect of some medicines to treat bronchial asthma may be disturbed. Method CR should not be used in severe forms of bronchial asthma;
if you suffer from diabetes mellitus: Metoprolol may mask the symptoms of low blood sugar. It is necessary to regularly check blood sugar;
if you have a mild form of a certain heart rhythm disorder (first degree AV block);
if you have a type of chest pain (angina pectoris) called Princeton's angina;
if you suffer from mild or moderate blood circulation disorders in the arms / legs;
if you have high blood pressure due to a tumor of the adrenal medulla (pheochromocytoma). Prior to and during treatment with metoprolol, an alpha-receptor blocker should be used;
if you have an overactive thyroid gland;
if you are undergoing surgery: you must tell the anesthesiologist before taking the operation that you are using Metostad CR;
if you have a tendency to allergic reactions: metoprolol may increase both the sensitivity to allergens (allergens) and the severity of severe common allergic reactions;
if you suffer from psoriasis.
Children and Juvenile
The following substances may increase the concentration of metoprolol in the blood and thus enhance the effect of Method CR:

Alcohol;
Medicines for the treatment of high levels of gastric acid such as cimetidine;
Blood pressure lowering drugs like hydralazine;
Some medicines to treat depression such as paroxetine, fluoxetine and sertraline;
Insomnia medications such as diphenhydramine;
Some substances for the treatment of joint disorders such as hydroxychloroquine and celecoxib;
Some medicines for the treatment of fungal infections (terbinafine);
Neuroleptics (e.g., chlorpromazine, triflupromazine, chlorprotyxene);
Some medicines to treat heart rhythm disorders like amiodarone, quinidine and possibly propafenone;
Some medicines to treat allergies.
If you also use anti-inflammatory drugs (such as indomethacin or other prostaglandin synthetase inhibitors), the blood pressure lowering effect of beta-receptor blockers may be impaired.
Rifampicin (an antibiotic for treatment of, for example, tuberculosis) weakens the blood pressure lowering effect of metoprolol.
Beta-receptor blockers can suppress insulin release in patients with type 2 diabetes. You should regularly control your blood sugar. If necessary, your doctor will adjust your blood sugar lowering (insulin and oral antidiabetic) therapy.
If Metoda CR and noradrenaline or adrenaline (neurotransmitters that occur naturally in the body and have a stimulating effect on the cardiovascular system and therefore increase blood pressure), or medicines with similar effects are taken together, your blood pressure may be markedly rose.
The effect of adrenaline in the treatment of hypersensitivity reactions may be impaired.
Metoprolol may reduce the release of other medicines (for example lidocaine used for local anesthesia).
If concomitant treatment with clonidine (a medicine used to treat high blood pressure) should be stopped, Metodist CR should be stopped several days before clonidine.

Metostad CR with food, beverages and alcohol
Metoprolol and alcohol can mutually enhance their sedative effects. Therefore, you should not drink alcohol while taking metoprolol.

Pregnancy and breastfeeding
If you are pregnant or are breast-feeding, think you may be pregnant or plan to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.

Pregnancy
During pregnancy, metoprolol should be used only with a strict indication and after careful consideration of the benefit-risk from the attending physician. There is evidence that metoprolol reduces the placental blood supply and can therefore cause growth disturbances in the fetus.
Metoprolol therapy should be stopped 48 - 72 hours before the calculated birth term. If this is not possible, the newborn should be observed carefully for 48 to 72 hours after birth.

Breastfeeding
Metoprolol accumulates in breast milk.
Although side effects can not be expected when metoprolol is used at therapeutic doses, infants should be monitored for drug effects.

Driving and using machines
Dizziness and fatigue may occur during treatment with Method. Your ability to react may be altered to such an extent as to affect your ability to drive, operate machinery or operate without adequate protective equipment. This is particularly true when alcohol is consumed at the same time or when the dose of metoprolol is increased.

Metostad CR contains sucrose
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3. How to take Metostad CR
Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist. Unless your doctor tells you otherwise, the recommended dose is:

Therapeutic indication: Ordinary dose, once daily: If necessary, the daily dose may be increased as follows:
High blood pressure 1 prolonged-release tablet of 47.5 mg;
1/2 prolonged-release tablet of 95 mg. Maximum dose:
4 prolonged-release tablets of 47.5 mg;
2 prolonged-release tablets of 95 mg;
1 prolonged-release tablet of 190 mg or another use of another medicine to lower blood pressure.
Poor blood supply to the coronary arteries (ischemic heart disease, angina) 1 to 4 prolonged-release tablets of 47.5 mg;
1/2 to 2 prolonged-release tablets of 95 mg.
Other amounts of the active substance per dose are also available to treat this condition. Maximum dose:
4 prolonged-release tablets of 47.5 mg;
2 prolonged-release tablets of 95 mg;
1 prolonged-release tablet of 190 mg or another use of another medicine to lower blood pressure.
Disturbances associated with
Prolonged-release tablets with a suitable amount of the active substance are available for this dose.

Patients with impaired renal function
No dose adjustment is necessary.

Patients with impaired hepatic function
The dose may need to be lowered in patients with severe hepatic impairment, such as patients with an artificial pressure-relieving vein (orthostatic suture).

Children and adolescents
High blood pressure: For children 6 years of age and over, the dose depends on the weight of the child. The doctor will determine the correct dose for your child.
The usual starting dose is 0.5 mg / kg once a day but not to exceed 50 mg. The dose will be adjusted to the nearest active tablet. Your doctor may increase the dose to 2.0 mg / kg depending on the blood pressure response.
Doses greater than 200 mg once daily have not been studied in children and adolescents.
Method CR tablets are not recommended for children under 6 years of age.

Adult patients over 80 years of age
There is insufficient data on the use of metoprolol in patients over 80 years of age.
Therefore, special caution should be exercised when increasing the dose in these patients.

Application method
The tablets should be taken once a day, preferably with breakfast.
The tablets should be swallowed whole or divided, but should not be chewed or crushed. They should be taken with water (at least 1/2 cup).

Duration of treatment
The duration of treatment is determined by your doctor.

If you take more than the required CR Method dose
Contact your doctor or emergency doctor immediately to decide what measures to take based on the amount of tablets you are taking. Keep the package at your fingertips so that your doctor knows what amount of active substance you have taken and can take the appropriate measures.
Depending on the degree of overdose, the following symptoms may occur: pronounced drop in blood pressure, slow heartbeat, heart rhythm disturbances, heart failure, circulatory collapse, cardiac arrest, narrowing / breath cramps, unconsciousness (even coma) , vomiting and bluish-red coloration of the skin and mucous membranes (cyanosis).
With concomitant use of alcohol, blood pressure lowering drugs, quinidine (a medicine to treat heart rhythm disturbances) or barbiturates (sedatives), symptoms may get worse.
The first signs of overdose occur from 20 minutes to 2 hours after taking the drug.

If you have forgotten to accept Metostad CR
Do not take a double dose to make up for the missed tablet. Continue to take your tablets as prescribed.

If you stop taking Metostad CR
If you want to discontinue or prematurely stop treatment with Metod CR, talk to your doctor.
Treatment with beta-blocker blockers should not be stopped abruptly. If treatment should be stopped, it should always be done slowly for a period of at least 2 weeks, if possible by gradually digesting the dose until the lowest dose of 1/2 tablet of 23.75 mg ( equivalent to 11.88 mg of metoprolol succinate). This last dose should be taken at least 4 days before the treatment is stopped definitively. If any symptoms occur, the dose should be reduced more slowly.
Abrupt withdrawal of beta-blocker blockers may lead to worsening of heart failure and may increase the risk of heart attack and sudden cardiac death.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everyone gets them.

Please tell your doctor or emergency doctor immediately if you notice one or more of the following:

heart pain;
panting;
yellowing of the skin and / or eyes (this may be a sign of inflammation of the liver).
The following side effects may occur during treatment with this medicine:
Very common (may affect more than 1 in 10 people):

pronounced drop in blood pressure, also when standing up, very rarely with unconsciousness;
fatigue.
Common (may affect up to 1 in 10 people):

slow heartbeat (bradycardia), feeling of loss of balance (very rarely with unconsciousness), feeling uneven or severe palpitations (palpitations);
dizziness, headache;
breathlessness in physical effort;
nausea, stomach pain, diarrhea, constipation;
cold hands and feet.
Uncommon (may affect up to 1 in 100 people):

transient worsening of heart failure symptoms, a certain type of heart rhythm disorder (first degree AV block), cardiac arrest;
tingling (paraesthesia);
spasms of the bronchi;
vomiting;
skin changes, rashes similar to psoriasis, increased sweating;
muscle cramps;
weight gain;
water retention in the tissue
How to Store Metostad CR
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the carton and blister after "EXP" and "EXP". The expiry date refers to the last day of that month.
High density polyethylene (HDPE) bottle: To be used within 6 months of opening.
Do not store above 25 ° C.
Do not dispose of medicines in the sewage system or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.

6. Package Contents and Additional Information
What contains Metostad CR
The active substance is metoprolol succinate (Ph.Eur.).
Each prolonged-release tablet contains 23.75 mg / 47.5 mg / 95 mg / 190 mg metoprolol succinate (Ph.Eur.) Equivalent to 25 mg / 50 mg / 100 mg / 200 mg metoprolol tartrate.

The other ingredients are:

Tablet core: sucrose, maize starch, macrogol 6000, polyacrylate dispersion 30%, talc, povidone K, microcrystalline cellulose, magnesium stearate (Ph.Eur.), Colloidal silicon dioxide, anhydrous;
Tablet wrap: hypromellose, talc, macrogol 6000, titanium dioxide (E171).
What CRT looks like and what the package contains
Method CR 23.75 mg prolonged-release tablets:
White to off-white, oblong, biconvex, film-coated tablets scored on both sides. The tablet length is between 9.0 and 9.4 mm and the width is between 4.0 and 4.4 mm.
The tablet can be divided into two equal doses.

Metostad CR 47.5 mg prolonged-release tablets:
White to off-white, oblong, biconvex, film-coated tablets scored on both sides. The tablet length is between 12.0 and 12.4 mm and the width is between 5.5 and 5.9 mm.
The tablet can be divided into two equal doses.

Metostad CR 95 mg prolonged-release tablets:
White to off-white, oblong, biconvex, film-coated tablets scored on both sides. The tablet length is between 15.0 and 15.4 mm and the width is between 7.0 and 7.4 mm.
The tablet can be divided into two equal doses.










 

 

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